Natural antimicrobials synergistically coupled with nanomotors: An innovative strategy for biofilm eradication
Por:
S. MEDAGLIA, A. ESCUDERO, A. MORELLÁ-AUCEJO, F. HICKE, M. REYES-TORRES, L. MARIN-FERRANDIS, P. AMORÓS, M. MARCOS, A. BERNARDOS, P. DÍEZ and R. MARTÍNEZ-MÁÑEZ
Publicada:
1 jul 2025
Ahead of Print:
1 abr 2025
Resumen:
Biofilms are one of the most important problems occurring in industrial environments, especially in food industry. The possibility of foodborne disease outbreaks as a result of biofilm-food cross-contamination is a distinct concern, along with the substantial costs associated with food spoilage and biofilm control. Besides, despite daily cleaning and disinfection, many bacteria grow in machines and surfaces in food processing plants, some of them forming biofilms. A promising procedure for disinfection and biofilm elimination could be the use of hybrid antimicrobial nanomaterials endowed with motion (i.e., nanomotors). Herein, we report Janus nanoparticles based on the conjunction of platinum and mesoporous silica nanoparticles, functionalized with a derivative of a natural antimicrobial compound, vanillin. The engineered nanomotors combine H2O2-triggered self-propulsion with the antimicrobial activity of vanillin, allowing enhanced physical penetration into the 3D matrix formed by the exopolymeric substances generated in monospecies (Staphylococcus aureus) and multispecies (S. aureus and Escherichia coli) biofilms and the subsequent elimination of pathogenic cells.
Filiaciones:
S. MEDAGLIA:
Univ Valencia UV, Univ Politecn Valencia UPV, Inst Interuniv Invest Reconocimiento Mol & Desarro, Camino Vera S-N, Valencia 46022, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
:
Univ Valencia UV, Univ Politecn Valencia UPV, Inst Interuniv Invest Reconocimiento Mol & Desarro, Camino Vera S-N, Valencia 46022, Spain
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermedad, Eduardo Primo Yufera 3, Valencia 46012, Spain
F. HICKE:
Univ Valencia UV, Univ Politecn Valencia UPV, Inst Interuniv Invest Reconocimiento Mol & Desarro, Camino Vera S-N, Valencia 46022, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
M. REYES-TORRES:
Univ Valencia UV, Univ Politecn Valencia UPV, Inst Interuniv Invest Reconocimiento Mol & Desarro, Camino Vera S-N, Valencia 46022, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
L. MARIN-FERRANDIS:
Univ Valencia UV, Univ Politecn Valencia UPV, Inst Interuniv Invest Reconocimiento Mol & Desarro, Camino Vera S-N, Valencia 46022, Spain
P. AMORÓS:
Univ Valencia, Inst Ciencia Mat ICMUV, Paterna 46980, Spain
:
Univ Valencia UV, Univ Politecn Valencia UPV, Inst Interuniv Invest Reconocimiento Mol & Desarro, Camino Vera S-N, Valencia 46022, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Univ Politecn Valencia, Dept Quim, Cami Vera S-N, Valencia 46022, Spain
:
Univ Valencia UV, Univ Politecn Valencia UPV, Inst Interuniv Invest Reconocimiento Mol & Desarro, Camino Vera S-N, Valencia 46022, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Univ Politecn Valencia, Dept Quim, Cami Vera S-N, Valencia 46022, Spain
P. DÍEZ:
Univ Valencia UV, Univ Politecn Valencia UPV, Inst Interuniv Invest Reconocimiento Mol & Desarro, Camino Vera S-N, Valencia 46022, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Univ Politecn Valencia, Unidad Mixta Invest Nanomed & Sensores, Inst Invest Sanitaria Fe IIS Fe, Av Fernando Abril Martorell 106, Valencia 46026, Spain
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