Pd2L4 Metal-Organic Cages with Perfluoroalkyl Edges: Ligand Design and Synthesis
Por:
G. FIORINI, N. PAIRAULT, C. VICENT, R. MARTINEZ-MÁÑEZ, N. MCCLENAGHAN and V. MARTI-CENTELLES
Publicada:
1 nov 2025
Ahead of Print:
1 sep 2025
Resumen:
Molecular cages are versatile supramolecular architectures with applications in guest encapsulation, catalysis, and sensing. This study reports the first Pd2L4 cage where vertices are bridged by-(CF2)n-chains. Cage synthesis is achieved by the self-assembly of a ligand comprising a perfluorinated alkyl chain grafted with terminal pyridines and Pd(II). While the synthesis with a ligand comprising alpha,omega-monosubstituted pyridines partially produces the desired cage, the further design of two ligands with methoxy groups at the meta or para positions relative to the N-atom greatly enhances the coordination strength between the metal centre and the pyridine group. The para-substituted ligand quantitatively yields the most stable Pd2L4 cage. These findings highlight the influence of electronic effects on coordination-driven self-assembly and provide a pathway for designing robust and functional metal-organic cages containing perfluorinated edges. Additionally, we performed host-guest experiments that show a good affinity with environmentally concerning contaminant perfluorooctanoic acid. In summary, we developed Pd2L4 metal-organic cages with perfluoroalkyl edges that show good stability and promising host-guest properties.
Filiaciones:
G. FIORINI:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarro, Valencia 46022, Spain
N. PAIRAULT:
Univ Bordeaux, CNRS, Inst Sci Mol, F-33405 Talence, France
C. VICENT:
Univ Jaume 1, Serv Cent Instrumentacio Cient, Castellon de La Plana 12071, Spain
:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarro, Valencia 46022, Spain
Univ Politecn Valencia, Dept Quim, Valencia 46022, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed, Valencia 46022, Spain
Univ Politecn Valencia, Unidad Mixta Invest Nanomed & Sensores, Inst Invest Sanitaria La Fe IISLAFE, Valencia 46026, Spain
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermedad, Valencia 46012, Spain
N. MCCLENAGHAN:
Univ Bordeaux, CNRS, Inst Sci Mol, F-33405 Talence, France
V. MARTI-CENTELLES:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarro, Valencia 46022, Spain
Univ Politecn Valencia, Dept Quim, Valencia 46022, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed, Valencia 46022, Spain
Green Submitted, gold
|