Whole exome sequencing and machine learning germline analysis of individuals presenting with extreme phenotypes of high and low risk of developing tobacco-associated lung adenocarcinoma.
Por:
Patiño-García A, Guruceaga E, Andueza MP, Ocón M, Fodop Sokoudjou JJ, de Villalonga Zornoza N, Alkorta-Aranburu G, Uria IT, Gurpide A, Camps C, Jantus-Lewintre E, Navamuel-Andueza M, Sanmamed MF, Melero I, Elgendy M, Fusco JP, Zulueta JJ, de-Torres JP, Bastarrika G, Seijo L, Pio R, Montuenga LM, Hernáez M, Ochoa I and Perez-Gracia JL
Publicada:
1 abr 2024
Ahead of Print:
1 mar 2024
Resumen:
Tobacco is the main risk factor for developing lung cancer. Yet, while some heavy smokers develop lung cancer at a young age, other heavy smokers never develop it, even at an advanced age, suggesting a remarkable variability in the individual susceptibility to the carcinogenic effects of tobacco. We characterized the germline profile of subjects presenting these extreme phenotypes with Whole Exome Sequencing (WES) and Machine Learning (ML).
Filiaciones:
Patiño-García A:
Department of Pediatrics and Clinical Genetics, Clínica Universidad de Navarra (CUN), Cancer Center Clínica Universidad de Navarra (CCUN), Program in Solid Tumors, Center for Applied Medical Research (Cima) and Navarra Institute for Health Research (IdisNA), University of Navarra, Pamplona, Spain
Guruceaga E:
Bioinformatics Platform, Cima and IdisNA, University of Navarra, Pamplona, Spain
Andueza MP:
Department of Oncology, CUN, CCUN and IdisNA, University of Navarra, Pamplona, Spain
Ocón M:
Pulmonary Department, CUN, CCUN and IdisNA, University of Navarra, Pamplona, Spain
Fodop Sokoudjou JJ:
Electrical and Electronic Engineering Department, Tecnun, University of Navarra, San Sebastian, Spain
de Villalonga Zornoza N:
Electrical and Electronic Engineering Department, Tecnun, University of Navarra, San Sebastian, Spain
Alkorta-Aranburu G:
CIMA LAB Diagnostics and IdisNA, University of Navarra, Pamplona, Spain
Uria IT:
Bioinformatics Platform, Cima and IdisNA, University of Navarra, Pamplona, Spain
Gurpide A:
Department of Oncology, CUN, CCUN and IdisNA, University of Navarra, Pamplona, Spain
:
Department of Medical Oncology, Hospital General Universitario de Valencia, Unidad Mixta TRIAL (Fundación para la Investigación del Hospital General Universitario de Valencia y Centro de Investigación Príncipe Felipe) and Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Valencia, Spain
:
Department of Biotechnology, Universitat Politècnica de València, Unidad Mixta TRIAL (Fundación para la Investigación del Hospital General Universitario de Valencia y Centro de Investigación Príncipe Felipe) and CIBERONC, Valencia, Spain
Navamuel-Andueza M:
Pulmonary Department, CUN, CCUN and IdisNA, University of Navarra, Pamplona, Spain
Sanmamed MF:
Department of Oncology, CUN, Division of Immunology, Cima, CCUN, IdisNA and CIBERONC, University of Navarra, Pamplona, Spain
Melero I:
Division of Immunology, Cima and Immunotherapy, CUN, CCUN, IdisNA and CIBERONC, University of Navarra, Pamplona, Spain
Elgendy M:
Institute for Clinical Chemistry and Laboratory Medicine, Mildred-Scheel Early Career Center, National Center for Tumor Diseases Dresden (NCT/UCC), University Hospital and Faculty of Medicine, Medical Clinic I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Laboratory of Cancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
Fusco JP:
Department of Medical Oncology Hospital La Luz, Quirón, Madrid, Spain
Zulueta JJ:
Pulmonary, Critical Care, and Sleep Division, Mount Sinai Morningside Hospital, New York, USA
de-Torres JP:
Pulmonary Department, CUN, CCUN and IdisNA, University of Navarra, Pamplona, Spain
Bastarrika G:
Department of Radiology, CUN, CCUN and IdisNA, Pamplona, Spain
Seijo L:
Pulmonary Department, CUN, CCUN and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), University of Navarra, Madrid, Spain
Pio R:
Program in Solid Tumors, Cima -CCUN, Department of Biochemistry and Genetics, School of Science, IdisNA and CIBERONC, University of Navarra, Pamplona, Spain
Montuenga LM:
Program in Solid Tumors, Cima, Department of Pathology, Anatomy and Physiology, Schools of Medicine and Sciences, CCUN, IdisNA and CIBERONC, University of Navarra, Pamplona, Spain
Hernáez M:
Computational Biology Program, Cima, Data Science and Artificial Intelligence Institute (DATAI), CCUN, IdisNA and CIBERONC, University of Navarra, Pamplona, Spain
Ochoa I:
Electrical and Electronic Engineering Department, Tecnun, DATAI, University of Navarra, San Sebastian, Spain
Perez-Gracia JL:
Department of Oncology, CUN, CCUN, IdisNA and CIBERONC, University of Navarra, Pamplona, Spain
Green Published, gold
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