Synergistic antimicrobial photodynamic therapy using gated mesoporous silica nanoparticles containing curcumin and polymyxin B
Por:
S. MEDAGLIA, I. OTRI, A. BERNARDOS, M. MARCOS, E. AZNAR, F. SANCENÓN and R. MARTÍNEZ-MÁÑEZ
Publicada:
10 abr 2024
Ahead of Print:
1 mar 2024
Resumen:
Photodynamic Therapy is a therapy based on combining a non-toxic compound, known as photosensitizer (PS), and irradiation with light of the appropriate wavelength to excite the PS molecule. The photon absorption by the PS leads to reactive oxygen species generation and a subsequent oxidative burst that causes cell damage and death. In this work, we report an antimicrobial nanodevice that uses the activity of curcumin (Cur) as a PS for antimicrobial Photodynamic Therapy (aPDT), based on mesoporous silica nanoparticles in which the action of the classical antibiotic PMB is synergistically combined with the aPDT properties of curcumin to combat bacteria. The synergistic effect of the designed gated device in combination with irradiation with blue LED light (470 nm) is evaluated against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus epidermidis. The results show that the nanodevice exhibits a noteworthy antibacterial activity against these microorganisms, a much more significant effect than free Cur and PMB at equivalent concentrations. Thus, 0.1 mu g/mL of MSNs-Cur-PMB eliminates a bacterial concentration of about 105 CFU/mL of E. coli, while 1 mu g/mL of MSNs-Cur-PMB is required for P. aeruginosa and S. epidermidis. In addition, antibiofilm activity against the selected bacteria was also tested. We found that 0.1 mg/mL of MSNs-Cur-PMB inhibited 99 % biofilm formation for E. coli, and 1 mg/mL of MSNs-CurPMB achieved 90 % and 100 % inhibition of biofilm formation for S. epidermidis and P. aeruginosa, respectively.
Filiaciones:
S. MEDAGLIA:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarro, Valencia, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
I. OTRI:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarro, Valencia, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
A. BERNARDOS:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarro, Valencia, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Univ Politecn Valencia, Dept Quim, Cami Vera S-N, Valencia 46022, Spain
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermedad, Valencia, Spain
M. MARCOS:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarro, Valencia, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Univ Politecn Valencia, Dept Quim, Cami Vera S-N, Valencia 46022, Spain
Univ Politecn Valencia, Unidad Mixta Invest Nanomed & Sensores, Inst Invest Sanitaria La Fe IISLAFE, Av Fernando Abril Martorell 106, Valencia 46026, Spain
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermedad, Valencia, Spain
:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarro, Valencia, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Univ Politecn Valencia, Dept Quim, Cami Vera S-N, Valencia 46022, Spain
Univ Politecn Valencia, Unidad Mixta Invest Nanomed & Sensores, Inst Invest Sanitaria La Fe IISLAFE, Av Fernando Abril Martorell 106, Valencia 46026, Spain
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermedad, Valencia, Spain
F. SANCENÓN:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarro, Valencia, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Univ Politecn Valencia, Dept Quim, Cami Vera S-N, Valencia 46022, Spain
Univ Politecn Valencia, Unidad Mixta Invest Nanomed & Sensores, Inst Invest Sanitaria La Fe IISLAFE, Av Fernando Abril Martorell 106, Valencia 46026, Spain
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermedad, Valencia, Spain
:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarro, Valencia, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Univ Politecn Valencia, Dept Quim, Cami Vera S-N, Valencia 46022, Spain
Univ Politecn Valencia, Unidad Mixta Invest Nanomed & Sensores, Inst Invest Sanitaria La Fe IISLAFE, Av Fernando Abril Martorell 106, Valencia 46026, Spain
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermedad, Valencia, Spain
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