BODIPY doping of covalent organic frameworks-based nanomaterials: A novel strategy towards biomedical applications
Por:
F. SUAREZ-BLAS, M. MARTINEZ-FERNANDEZ, A. PRIETO-CASTANEDA, A. GARCIA-FERNANDEZ, J. MARTINEZ, M. RAMOS, M. ORTIZ, R. MARTINEZ-MANEZ and J. SEGURA
Publicada:
1 nov 2023
Ahead of Print:
1 jul 2023
Resumen:
Covalent organic Frameworks (COFs) are a class of crystalline macromolecular materials build-up by monomers with specific symmetries or functionalities. There are important limitations in the synthesis of highly ordered COFs, such as the shape and packing of the building blocks. Thus, the presence of fluorine atoms that lie perpendicular to the bisecting plane of BODIPY derivatives together with the presence of four bulky methyl groups could hinder the crystallization process in COF synthesis. For that reason, BODIPY-based COFs are rarely incorporated to COF networks. In this work, following the mixed linker strategy, a pre-synthetic method to dope COF structures with BODIPY units was developed. The materials have been processed into fluorescent Covalent Organic Nanosheets (CONs) with defined particle-size distributions around 100 nm, suitable for cellular biomedical applications. The viability of the CONs was evaluated using Sk-Mel-103 cells, demonstrating the internalization showing 100% cell viability. We envisage that this work could accelerate the discovery of new COF-based materials for biomedical sciences.
Filiaciones:
F. SUAREZ-BLAS:
Univ Complutense Madrid, Fac CC Quim, Dept Quim Organ, Madrid 28040, Spain
Univ Rey Juan Carlos, Dept Tecnol Quim & Medioambiental, Mostoles 28933, Spain
M. MARTINEZ-FERNANDEZ:
Univ Complutense Madrid, Fac CC Quim, Dept Quim Organ, Madrid 28040, Spain
A. PRIETO-CASTANEDA:
Univ Complutense Madrid, Fac CC Quim, Dept Quim Organ, Madrid 28040, Spain
:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarro, Valencia 46022, Spain
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV, CIPF Invest Mecanismos Enfermedades & Nanomed, Valencia 46012, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed, Madrid, Spain
J. MARTINEZ:
CSIC, Dept Nanoestruct Superf Recubrimientos & Astrofis, Inst Ciencia Mat Madrid ICMM, Madrid 28049, Spain
M. RAMOS:
Univ Rey Juan Carlos, Dept Tecnol Quim & Medioambiental, Mostoles 28933, Spain
M. ORTIZ:
Univ Complutense Madrid, Fac CC Quim, Dept Quim Organ, Madrid 28040, Spain
:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarro, Valencia 46022, Spain
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV, CIPF Invest Mecanismos Enfermedades & Nanomed, Valencia 46012, Spain
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed, Madrid, Spain
Univ Politecn Valencia, Unidad Mixta Invest Nanomed & Sensores, IIS La Fe, Valencia 46026, Spain
J. SEGURA:
Univ Complutense Madrid, Fac CC Quim, Dept Quim Organ, Madrid 28040, Spain
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