Tcf20 deficiency is associated with increased liver fibrogenesis and alterations in mitochondrial metabolism in mice and humans.
Por:
Córdoba-Jover B, Ribera J, Portolés I, Lecue E, Rodriguez-Vita J, Pérez-Sisqués L, Mannara F, Solsona-Vilarrasa E, García-Ruiz C, Fernández-Checa JC, Casals G, Rodríguez-Revenga L, Álvarez-Mora MI, Arteche-López A, Díaz de Bustamante A, Calvo R, Pujol A, Azkargorta M, Elortza F, Malagelada C, Pinyol R, Huguet-Pradell J, Melgar-Lesmes P, Jiménez W and Morales-Ruiz M
Publicada:
1 ago 2023
Ahead of Print:
1 jun 2023
Resumen:
Transcription co-activator factor 20 (TCF20) is a regulator of transcription factors involved in extracellular matrix remodelling. In addition, TCF20 genomic variants in humans have been associated with impaired intellectual disability. Therefore, we hypothesized that TCF20 has several functions beyond those described in neurogenesis, including the regulation of fibrogenesis.
Filiaciones:
Córdoba-Jover B:
Biochemistry and Molecular Genetics Department, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Ribera J:
Biochemistry and Molecular Genetics Department, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
CIBERehd, Instituto de Salud Carlos III, Madrid, Spain
Portolés I:
Biochemistry and Molecular Genetics Department, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Lecue E:
Biochemistry and Molecular Genetics Department, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
:
Tumour-Stroma Communication Laboratory, Centro de Investigación Príncipe Felipe, Valencia, Spain
Pérez-Sisqués L:
Department of Biomedicine-Biochemistry Unit, School of Medicine University of Barcelona, Barcelona, Spain
Mannara F:
Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Barcelona, Spain
Solsona-Vilarrasa E:
CIBERehd, Instituto de Salud Carlos III, Madrid, Spain
Cell Death and Proliferation, Institute of Biomedical Research of Barcelona (IIBB), Consejo Superior Investigaciones Científicas (CSIC), Liver Unit, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
García-Ruiz C:
CIBERehd, Instituto de Salud Carlos III, Madrid, Spain
Cell Death and Proliferation, Institute of Biomedical Research of Barcelona (IIBB), Consejo Superior Investigaciones Científicas (CSIC), Liver Unit, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
USC Research Center for ALPD, Keck School of Medicine, Los Angeles, California, USA
Fernández-Checa JC:
CIBERehd, Instituto de Salud Carlos III, Madrid, Spain
Cell Death and Proliferation, Institute of Biomedical Research of Barcelona (IIBB), Consejo Superior Investigaciones Científicas (CSIC), Liver Unit, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
USC Research Center for ALPD, Keck School of Medicine, Los Angeles, California, USA
Casals G:
Biochemistry and Molecular Genetics Department, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
CIBERehd, Instituto de Salud Carlos III, Madrid, Spain
Department of Biomedicine-Biochemistry Unit, School of Medicine University of Barcelona, Barcelona, Spain
Rodríguez-Revenga L:
Biochemistry and Molecular Genetics Department, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
CIBER of Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain
Álvarez-Mora MI:
Biochemistry and Molecular Genetics Department, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
CIBER of Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain
Genetics Department, 12 de Octubre University Hospital, Madrid, Spain
Arteche-López A:
Genetics Department, 12 de Octubre University Hospital, Madrid, Spain
UDISGEN (Unidad de Dismorfología y Genética), 12 de Octubre University Hospital, Madrid, Spain
Díaz de Bustamante A:
Unidad de Genética, Hospital Universitario de Móstoles, Madrid, Spain
Calvo R:
Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Barcelona, Spain
Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic of Barcelona. School of Medicine, University of Barcelona, Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), Madrid, Spain
Pujol A:
Unidad de Animales Transgénicos UAT-CBATEG, Universitat Autònoma de Barcelona, Cerdanyola del Valles, Spain
Azkargorta M:
Proteomics Platform, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), CIBERehd, Derio, Spain
Elortza F:
Proteomics Platform, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), CIBERehd, Derio, Spain
Malagelada C:
Department of Biomedicine-Biochemistry Unit, School of Medicine University of Barcelona, Barcelona, Spain
Pinyol R:
Translational Research in Hepatic Oncology Group, Liver Unit, IDIBAPS, Barcelona Clínic Hospital, University of Barcelona, Barcelona, Spain
Huguet-Pradell J:
Translational Research in Hepatic Oncology Group, Liver Unit, IDIBAPS, Barcelona Clínic Hospital, University of Barcelona, Barcelona, Spain
Melgar-Lesmes P:
Biochemistry and Molecular Genetics Department, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
CIBERehd, Instituto de Salud Carlos III, Madrid, Spain
Department of Biomedicine-Biochemistry Unit, School of Medicine University of Barcelona, Barcelona, Spain
Jiménez W:
Biochemistry and Molecular Genetics Department, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
CIBERehd, Instituto de Salud Carlos III, Madrid, Spain
Department of Biomedicine-Biochemistry Unit, School of Medicine University of Barcelona, Barcelona, Spain
Morales-Ruiz M:
Biochemistry and Molecular Genetics Department, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
CIBERehd, Instituto de Salud Carlos III, Madrid, Spain
Department of Biomedicine-Biochemistry Unit, School of Medicine University of Barcelona, Barcelona, Spain
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