CCNE1 and PLK1 Mediate Resistance to Palbociclib in HR+/HER2- Metastatic Breast Cancer.
Por:
Guerrero-Zotano Á, Belli S, Zielinski C, Gil-Gil M, Fernandez-Serra A, Ruiz-Borrego M, Ciruelos Gil EM, Pascual J, Muñoz-Mateu M, Bermejo B, Margeli Vila M, Antón A, Murillo L, Nissenbaum B, Liu Y, Herranz J, Fernández-García D, Caballero R, López-Guerrero JA, Bianco R, Formisano L, Turner N and Martín M
Publicada:
14 abr 2023
Resumen:
In hormone receptor-positive (HR+)/HER2- metastatic breast cancer (MBC), it is imperative to identify patients who respond poorly to cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) and to discover therapeutic targets to reverse this resistance. Non-luminal breast cancer subtype and high levels of CCNE1 are candidate biomarkers in this setting, but further validation is needed.
Filiaciones:
Guerrero-Zotano Á:
Medical Oncology, Instituto Valenciano de Oncología, Valencia, Spain
GEICAM Spanish Breast Cancer Group, Madrid, Spain
Belli S:
Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy
Zielinski C:
Medical Oncology, Central European Cancer Center, Wiener Privatklinik Hospital, Vienna, Austria
CECOG Central European Cooperative Oncology Group, Vienna, Austria
Gil-Gil M:
GEICAM Spanish Breast Cancer Group, Madrid, Spain
Institut Català d'Oncologia (ICO), Barcelona, Spain
IDIBELL, L'Hospitalet, Barcelona, Spain
Fernandez-Serra A:
Laboratory of Molecular Biology, Fundación Instituto Valenciano de Oncología, Valencia, Spain
Ruiz-Borrego M:
GEICAM Spanish Breast Cancer Group, Madrid, Spain
Medical Oncology, Hospital Universitario Virgen del Rocio, Sevilla, Spain
Ciruelos Gil EM:
GEICAM Spanish Breast Cancer Group, Madrid, Spain
Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain
Medical Oncology, HM Hospitales Madrid, Madrid, Spain
SOLTI Group on Breast Cancer Research, Barcelona, Spain
Pascual J:
GEICAM Spanish Breast Cancer Group, Madrid, Spain
Medical Oncology Intercenter Unit, Regional and Virgen de la Victoria University Hospitals, IBIMA, Málaga, Spain
Institute of Cancer Research and Royal Marsden, London, United Kingdom
Oncology Biomedical Research National Network (CIBERONC-ISCIII), Madrid, Spain
Muñoz-Mateu M:
GEICAM Spanish Breast Cancer Group, Madrid, Spain
Medical Oncology, Hospital Clinic de Barcelona, Barcelona, Spain
Translational Genomics and Targeted Therapeutics in Solid Tumors (IDIBAPS), Barcelona, Spain
Bermejo B:
GEICAM Spanish Breast Cancer Group, Madrid, Spain
Oncology Biomedical Research National Network (CIBERONC-ISCIII), Madrid, Spain
Medical Oncology, Hospital Clínico Universitario de Valencia, Medicine Department, Universidad Medicina Valencia, Valencia, Spain
Biomedical Research Institute INCLIVA, Valencia, Spain
Margeli Vila M:
GEICAM Spanish Breast Cancer Group, Madrid, Spain
B-ARGO Group, Catalan Institute of Oncology- Badalona, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
Antón A:
GEICAM Spanish Breast Cancer Group, Madrid, Spain
Oncology Biomedical Research National Network (CIBERONC-ISCIII), Madrid, Spain
Medical Oncology, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain
Murillo L:
GEICAM Spanish Breast Cancer Group, Madrid, Spain
Medical Oncology, Hospital Clínico de Zaragoza Lozano Blesa, Zaragoza, Spain
Nissenbaum B:
Meir Medical Center, Kfar Saba, Israel
Liu Y:
Pfizer, La Jolla, California
Herranz J:
GEICAM Spanish Breast Cancer Group, Madrid, Spain
Fernández-García D:
GEICAM Spanish Breast Cancer Group, Madrid, Spain
Caballero R:
GEICAM Spanish Breast Cancer Group, Madrid, Spain
:
Laboratory of Molecular Biology, Fundación Instituto Valenciano de Oncología, Valencia, Spain
IVO-CIPF Joint Research Unit of Cancer, Príncipe Felipe Research Center (CIPF), Valencia, Spain
Department of Pathology, School of Medicine, Catholic University of Valencia "San Vicente Mártir", Valencia, Spain
Bianco R:
Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy
Formisano L:
Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy
Turner N:
Institute of Cancer Research and Royal Marsden, London, United Kingdom
Martín M:
GEICAM Spanish Breast Cancer Group, Madrid, Spain
Oncology Biomedical Research National Network (CIBERONC-ISCIII), Madrid, Spain
Medical Oncology, Instituto de Investigación Sanitaria Gregorio Marañón, Medicine Department, Universidad Complutense, Madrid, Spain
Green Submitted, hybrid, Green Published
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