Semaphorin 3C exacerbates liver fibrosis.
Por:
De Angelis Rigotti F, Wiedmann L, Hubert MO, Vacca M, Hasan SS, Moll I, Carvajal S, Jiménez W, Starostecka M, Billeter AT, Müller-Stich B, Wolff G, Ekim-Üstünel B, Herzig S, Fandos-Ramo C, Krätzner R, Reich M, Keitel-Anselmino V, Heikenwälder M, Mogler C, Fischer A and Rodriguez-Vita J
Publicada:
1 oct 2023
Ahead of Print:
14 abr 2023
Resumen:
Chronic liver disease is a growing epidemic, leading to fibrosis and cirrhosis. TGF-ß is the pivotal profibrogenic cytokine that activates HSC, yet other molecules can modulate TGF-ß signaling during liver fibrosis. Expression of the axon guidance molecules semaphorins (SEMAs), which signal through plexins and neuropilins (NRPs), have been associated with liver fibrosis in HBV-induced chronic hepatitis. This study aims at determining their function in the regulation of HSCs.
Filiaciones:
:
Vascular Signaling and Cancer Division, German Cancer Research Center (DKFZ), Heidelberg, Germany
Tumor-Stroma Communication Laboratory, Centro de Investigación Príncipe Felipe, Valencia, Spain
Wiedmann L:
Vascular Signaling and Cancer Division, German Cancer Research Center (DKFZ), Heidelberg, Germany
Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany
Hubert MO:
Vascular Signaling and Cancer Division, German Cancer Research Center (DKFZ), Heidelberg, Germany
European Center for Angioscience (ECAS), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Vacca M:
Vascular Signaling and Cancer Division, German Cancer Research Center (DKFZ), Heidelberg, Germany
Hasan SS:
Vascular Signaling and Cancer Division, German Cancer Research Center (DKFZ), Heidelberg, Germany
Moll I:
Vascular Signaling and Cancer Division, German Cancer Research Center (DKFZ), Heidelberg, Germany
Carvajal S:
Service of Biochemistry and Molecular Genetics, Hospital Clinic Universitari, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Jiménez W:
Service of Biochemistry and Molecular Genetics, Hospital Clinic Universitari, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Department of Biomedicine, Medical and Health Sciences School, University of Barcelona, Barcelona, Spain
Starostecka M:
Vascular Signaling and Cancer Division, German Cancer Research Center (DKFZ), Heidelberg, Germany
Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany
European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany
Billeter AT:
Department of General, Visceral and Transplantation Surgery, University of Heidelberg Hospital, Heidelberg, Germany
Müller-Stich B:
Department of General, Visceral and Transplantation Surgery, University of Heidelberg Hospital, Heidelberg, Germany
Wolff G:
Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Centre Munich, Neuherberg, Germany
Joint Heidelberg-IDC Translational Diabetes Program, Department of Internal Medicine 1, Heidelberg University Hospital, Heidelberg, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany, and Chair Molecular Metabolic Control, Technical University Munich, Munich, Germany
Ekim-Üstünel B:
Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Centre Munich, Neuherberg, Germany
Joint Heidelberg-IDC Translational Diabetes Program, Department of Internal Medicine 1, Heidelberg University Hospital, Heidelberg, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany, and Chair Molecular Metabolic Control, Technical University Munich, Munich, Germany
Herzig S:
Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Centre Munich, Neuherberg, Germany
Joint Heidelberg-IDC Translational Diabetes Program, Department of Internal Medicine 1, Heidelberg University Hospital, Heidelberg, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany, and Chair Molecular Metabolic Control, Technical University Munich, Munich, Germany
:
Tumor-Stroma Communication Laboratory, Centro de Investigación Príncipe Felipe, Valencia, Spain
Krätzner R:
Department of Pediatrics and Adolescent Medicine, University Medical Center Göttingen, Göttingen, Germany
Reich M:
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital Magdeburg, Magdeburg, Germany
Chronic Inflammation and Cancer Division, German Cancer Research Center (DKFZ), Heidelberg, Germany
Keitel-Anselmino V:
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital Magdeburg, Magdeburg, Germany
Heikenwälder M:
Chronic Inflammation and Cancer Division, German Cancer Research Center (DKFZ), Heidelberg, Germany
Mogler C:
Institute of Pathology, Technical University of Munich, Munich, Germany
Fischer A:
Vascular Signaling and Cancer Division, German Cancer Research Center (DKFZ), Heidelberg, Germany
Institute for Clinical Chemistry, University Medical Center Göttingen, Göttingen, Germany
:
Vascular Signaling and Cancer Division, German Cancer Research Center (DKFZ), Heidelberg, Germany
Tumor-Stroma Communication Laboratory, Centro de Investigación Príncipe Felipe, Valencia, Spain
Green Submitted
|