Deciphering the sex bias in housekeeping gene expression in adipose tissue: a comprehensive meta-analysis of transcriptomic studies.
Por:
Guaita-Cespedes M, Grillo-Risco R, Hidalgo MR, Fernández-Veledo S, Burks DJ, de la Iglesia-Vayá M, Galán A and Garcia-Garcia F
Publicada:
18 abr 2023
Resumen:
As the housekeeping genes (HKG) generally involved in maintaining essential cell functions are typically assumed to exhibit constant expression levels across cell types, they are commonly employed as internal controls in gene expression studies. Nevertheless, HKG may vary gene expression profile according to different variables introducing systematic errors into experimental results. Sex bias can indeed affect expression display, however, up to date, sex has not been typically considered as a biological variable.
Filiaciones:
Guaita-Cespedes M:
Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), C/ Eduardo Primo Yúfera, 3, 46012, Valencia, Spain
Hematology Research Group, Instituto de Investigación Sanitaria La Fe (IIS La Fe), 46026, Valencia, Spain
Grillo-Risco R:
Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), C/ Eduardo Primo Yúfera, 3, 46012, Valencia, Spain
:
Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), C/ Eduardo Primo Yúfera, 3, 46012, Valencia, Spain
Fernández-Veledo S:
Department of Endocrinology and Nutrition and Research Unit, University Hospital of Tarragona Joan XXIII, Institut d'Investigaciò Sanitària Pere Virgili (IISPV), Tarragona, Spain
CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain
:
CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain
Molecular Neuroendocrinology Laboratory, Principe Felipe Research Center (CIPF), C/ Eduardo Primo Yúfera, 3, 46012, Valencia, Spain
:
Imaging Unit FISABIO-CIPF, Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana, 46012, Valencia, Spain
:
CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.
Molecular Neuroendocrinology Laboratory, Principe Felipe Research Center (CIPF), C/ Eduardo Primo Yúfera, 3, 46012, Valencia, Spain.
:
Bioinformatics and Biostatistics Unit, Principe Felipe Research Center (CIPF), C/ Eduardo Primo Yúfera, 3, 46012, Valencia, Spain.
gold, Green Published, Green Submitted
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