Characterization of Early Peripheral Immune Responses in Patients with Sepsis and Septic Shock.
Por:
Beltrán-García J, Osca-Verdegal R, Jávega B, Herrera G, O'Connor JE, García-López E, Casabó-Vallés G, Rodriguez-Gimillo M, Ferreres J, Carbonell N, Pallardó FV and García-Giménez JL
Publicada:
23 feb 2022
Resumen:
(1) Background: Sepsis is a life-threatening condition caused by an abnormal host response to infection that produces altered physiological responses causing tissue damage and can result in organ dysfunction and, in some cases, death. Although sepsis is characterized by a malfunction of the immune system leading to an altered immune response and immunosuppression, the high complexity of the pathophysiology of sepsis requires further investigation to characterize the immune response in sepsis and septic shock. (2) Methods: This study analyzes the immune-related responses occurring during the early stages of sepsis by comparing the amounts of cytokines, immune modulators and other endothelial mediators of a control group and three types of severe patients: critically ill non-septic patients, septic and septic shock patients. (3) Results: We showed that in the early stages of sepsis the innate immune system attempts to counteract infection, probably via neutrophils. Conversely, the adaptive immune system is not yet fully activated, either in septic or in septic shock patients. In addition, immunosuppressive responses and pro-coagulation signals are active in patients with septic shock. (4) Conclusions: The highest levels of IL-6 and pyroptosis-related cytokines (IL-18 and IL-1a) were found in septic shock patients, which correlated with D-dimer. Moreover, endothelial function may be affected as shown by the overexpression of adhesion molecules such as s-ICAM1 and E-Selectin during septic shock.
Filiaciones:
Beltrán-García J:
Center for Biomedical Research Network on Rare Diseases (CIBERER), Carlos III Health Institute, 46010 Valencia, Spain
INCLIVA Biomedical Research Institute, 46010 Valencia, Spain
Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain
Osca-Verdegal R:
Center for Biomedical Research Network on Rare Diseases (CIBERER), Carlos III Health Institute, 46010 Valencia, Spain
INCLIVA Biomedical Research Institute, 46010 Valencia, Spain
Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain
Jávega B:
Laboratory of Cytomics, Joint Research Unit CIPF-UVEG, University of Valencia, 46010 Valencia, Spain
Herrera G:
Flow Cytometry Unit, IIS INCLIVA, Fundación Investigación Hospital Clínico Valencia, 46010 Valencia, Spain
:
Laboratory of Cytomics, Joint Research Unit CIPF-UVEG, University of Valencia, 46010 Valencia, Spain
García-López E:
Center for Biomedical Research Network on Rare Diseases (CIBERER), Carlos III Health Institute, 46010 Valencia, Spain
EpiDisease S.L. (Spin-Off CIBER-ISCIII), Parc Científic de la Universitat de València, 46980 Paterna, Spain
Casabó-Vallés G:
EpiDisease S.L. (Spin-Off CIBER-ISCIII), Parc Científic de la Universitat de València, 46980 Paterna, Spain
Rodriguez-Gimillo M:
INCLIVA Biomedical Research Institute, 46010 Valencia, Spain
Intensive Care Unit, Clinical University Hospital of Valencia (HCUV), 46010 Valencia, Spain
Ferreres J:
INCLIVA Biomedical Research Institute, 46010 Valencia, Spain
Intensive Care Unit, Clinical University Hospital of Valencia (HCUV), 46010 Valencia, Spain
Carbonell N:
INCLIVA Biomedical Research Institute, 46010 Valencia, Spain
Intensive Care Unit, Clinical University Hospital of Valencia (HCUV), 46010 Valencia, Spain
:
Center for Biomedical Research Network on Rare Diseases (CIBERER), Carlos III Health Institute, 46010 Valencia, Spain
INCLIVA Biomedical Research Institute, 46010 Valencia, Spain
Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain
:
Center for Biomedical Research Network on Rare Diseases (CIBERER), Carlos III Health Institute, 46010 Valencia, Spain
INCLIVA Biomedical Research Institute, 46010 Valencia, Spain
Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain
Green Published, gold
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