Mesoporous Silica Materials as an Emerging Tool for Cancer Immunotherapy.
Por:
Escriche-Navarro B, Escudero A, Lucena-Sánchez E, Sancenón F, García-Fernández A and Martínez-Máñez R
Publicada:
1 sep 2022
Ahead of Print:
1 jul 2022
Resumen:
Cancer immunotherapy has emerged in the past decade as a promising strategy for treating many forms of cancer by stimulating the patient's immune system. Although immunotherapy has achieved some promising results in clinics, more efforts are required to improve the limitations of current treatments related to lack of effective and targeted cancer antigens delivery to immune cells, dose-limiting toxicity, and immune-mediated adverse effects, among others. In recent years, the use of nanomaterials has proven promising to enhance cancer immunotherapy efficacy and reduce side effects. Among nanomaterials, attention has been recently paid to mesoporous silica nanoparticles (MSNs) as a potential multiplatform for enhancing cancer immunotherapy by considering their unique properties, such as high porosity, and good biocompatibility, facile surface modification, and self-adjuvanticity. This review explores the role of MSN and other nano/micro-materials as an emerging tool to enhance cancer immunotherapy, and it comprehensively summarizes the different immunotherapeutic strategies addressed to date by using MSN.
Filiaciones:
Escriche-Navarro B:
Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM) Polytechnic University of Valencia-University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain
Universitat Politècnica de València, Joint Unit UPV-CIPF of Developmental Biology and Disease Models and Nanomedicine, Polytechnic University of Valencia (UPV)-Príncipe Felipe Research Center Foundation (CIPF), C/ Eduardo Primo Yúfera 3., Valencia, 46012, Spain
Joint Unit of Nanomedicine and Sensors, Polytechnic University of Valencia, IIS La Fe, Av. Fernando Abril Martorell, 106, Valencia, 46026, Spain
:
Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM) Polytechnic University of Valencia-University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain
Universitat Politècnica de València, Joint Unit UPV-CIPF of Developmental Biology and Disease Models and Nanomedicine, Polytechnic University of Valencia (UPV)-Príncipe Felipe Research Center Foundation (CIPF), C/ Eduardo Primo Yúfera 3., Valencia, 46012, Spain
:
Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM) Polytechnic University of Valencia-University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain
Universitat Politècnica de València, Joint Unit UPV-CIPF of Developmental Biology and Disease Models and Nanomedicine, Polytechnic University of Valencia (UPV)-Príncipe Felipe Research Center Foundation (CIPF), C/ Eduardo Primo Yúfera 3., Valencia, 46012, Spain
:
Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM) Polytechnic University of Valencia-University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain
Universitat Politècnica de València, Joint Unit UPV-CIPF of Developmental Biology and Disease Models and Nanomedicine, Polytechnic University of Valencia (UPV)-Príncipe Felipe Research Center Foundation (CIPF), C/ Eduardo Primo Yúfera 3., Valencia, 46012, Spain
Joint Unit of Nanomedicine and Sensors, Polytechnic University of Valencia, IIS La Fe, Av. Fernando Abril Martorell, 106, Valencia, 46026, Spain
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Av. Monforte de Lemos, 3-5. Pabellón 11., Planta 0, Madrid, 28029, Spain
:
Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM) Polytechnic University of Valencia-University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain
Universitat Politècnica de València, Joint Unit UPV-CIPF of Developmental Biology and Disease Models and Nanomedicine, Polytechnic University of Valencia (UPV)-Príncipe Felipe Research Center Foundation (CIPF), C/ Eduardo Primo Yúfera 3., Valencia, 46012, Spain
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Av. Monforte de Lemos, 3-5. Pabellón 11., Planta 0, Madrid, 28029, Spain
:
Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM) Polytechnic University of Valencia-University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain
Universitat Politècnica de València, Joint Unit UPV-CIPF of Developmental Biology and Disease Models and Nanomedicine, Polytechnic University of Valencia (UPV)-Príncipe Felipe Research Center Foundation (CIPF), C/ Eduardo Primo Yúfera 3., Valencia, 46012, Spain
Joint Unit of Nanomedicine and Sensors, Polytechnic University of Valencia, IIS La Fe, Av. Fernando Abril Martorell, 106, Valencia, 46026, Spain
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Av. Monforte de Lemos, 3-5. Pabellón 11., Planta 0, Madrid, 28029, Spain
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