Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis
Por:
A. PRIETO-CASTANEDA, F. GARCIA-GARRIDO, C. DIAZ-NORAMBUENA, B. ESCRICHE-NAVARRO, A. GARCIA-FERNANDEZ, J. BANUCLOS, E. REBOLLAR, I. GARCIA-MORENO, R. MARTINEZ-MANEZ, S. DE LA MOYA, A. AGARRABEITIA and M. ORTIZ
Publicada:
27 may 2022
Resumen:
We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprece-dented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY-BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis.
Filiaciones:
A. PRIETO-CASTANEDA:
Univ Complutense Madrid, Dept Quim Organ, Fac Ciencias Quim, Madrid 28040, Spain
F. GARCIA-GARRIDO:
Univ Complutense Madrid, Dept Quim Organ, Fac Ciencias Quim, Madrid 28040, Spain
C. DIAZ-NORAMBUENA:
Univ Pais Vasco EHU, Dept Quim Fis, Bilbao 48080, Spain
B. ESCRICHE-NAVARRO:
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermeda, Valencia 46012, Spain
Univ Politecn Valencia, Unidad Mixta Invest Nanomed & Sensores, IIS La Fe, Valencia 46026, Spain
Univ Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Univ Politecn Valencia, Valencia 46026, Spain
:
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermeda, Valencia 46012, Spain
Univ Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Univ Politecn Valencia, Valencia 46026, Spain
CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
J. BANUCLOS:
Univ Pais Vasco EHU, Dept Quim Fis, Bilbao 48080, Spain
E. REBOLLAR:
CSIC, Dept Sistemas Baja Dimensionalidad Superficies &, Inst Quim Fis Rocasolano, Madrid 28006, Spain
I. GARCIA-MORENO:
CSIC, Dept Sistemas Baja Dimensionalidad Superficies &, Inst Quim Fis Rocasolano, Madrid 28006, Spain
:
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermeda, Valencia 46012, Spain
Univ Politecn Valencia, Unidad Mixta Invest Nanomed & Sensores, IIS La Fe, Valencia 46026, Spain
Univ Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Univ Politecn Valencia, Valencia 46026, Spain
CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
S. DE LA MOYA:
Univ Complutense Madrid, Dept Quim Organ, Fac Ciencias Quim, Madrid 28040, Spain
A. AGARRABEITIA:
Univ Complutense Madrid, Dept Quim Organ, Fac Ciencias Quim, Madrid 28040, Spain
Univ Complutense Madrid, Secc Dept Quim Organ, Fac Opt & Optometria, Madrid 28037, Spain
M. ORTIZ:
Univ Complutense Madrid, Dept Quim Organ, Fac Ciencias Quim, Madrid 28040, Spain
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