Fluorogenic Detection of Human Serum Albumin Using Curcumin-Capped Mesoporous Silica Nanoparticles
Por:
I. OTRI, S. MEDAGLIA, E. AZNAR, F. SANCENON and R. MARTINEZ-MANEZ
Publicada:
1 feb 2022
Resumen:
Mesoporous silica nanoparticles loaded with rhodamine B and capped with curcumin are used for the selective and sensitive fluorogenic detection of human serum albumin (HSA). The sensing mesoporous silica nanoparticles are loaded with rhodamine B, decorated with aminopropyl moieties and capped with curcumin. The nanoparticles selectively release the rhodamine B cargo in the presence of HSA. A limit of detection for HSA of 0.1 mg/mL in PBS (pH 7.4)-acetonitrile 95:5 v/v was found, and the sensing nanoparticles were used to detect HSA in spiked synthetic urine samples.
Filiaciones:
I. OTRI:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Valencia 46022, Spain
Univ Politecn Valencia, Dept Quim, Camino Vera S-N, Valencia 46022, Spain
S. MEDAGLIA:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Valencia 46022, Spain
Univ Politecn Valencia, Dept Quim, Camino Vera S-N, Valencia 46022, Spain
:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Valencia 46022, Spain
Univ Politecn Valencia, Dept Quim, Camino Vera S-N, Valencia 46022, Spain
CIBER Bioingn Biomat & Nanomed CIBER BBN, Valencia 46022, Spain
Univ Politecn Valencia, Inst Invest Sanitaria La Fe IISLAFE, Unidad Mixta Invest Nanomed & Sensores, Valencia 46026, Spain
F. SANCENON:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Valencia 46022, Spain
Univ Politecn Valencia, Dept Quim, Camino Vera S-N, Valencia 46022, Spain
CIBER Bioingn Biomat & Nanomed CIBER BBN, Valencia 46022, Spain
Univ Politecn Valencia, Inst Invest Sanitaria La Fe IISLAFE, Unidad Mixta Invest Nanomed & Sensores, Valencia 46026, Spain
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF, Invest Mecanismos Enfermedades & Nanomed, Valencia 46100, Spain
:
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Valencia 46022, Spain
Univ Politecn Valencia, Dept Quim, Camino Vera S-N, Valencia 46022, Spain
CIBER Bioingn Biomat & Nanomed CIBER BBN, Valencia 46022, Spain
Univ Politecn Valencia, Inst Invest Sanitaria La Fe IISLAFE, Unidad Mixta Invest Nanomed & Sensores, Valencia 46026, Spain
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF, Invest Mecanismos Enfermedades & Nanomed, Valencia 46100, Spain
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