Body-fat sensor triggers ribosome maturation in the steroidogenic gland to initiate sexual maturation in Drosophila
Por:
S. JUAREZ-CARRENO, D. VALLEJO, J. CARRANZA-VALENCIA, M. PALOMINO-SCHATZLEIN, P. RAMON-CANELLAS, R. SANTORO, E. DE HARTOG, D. FERRES-MARCO, A. ROMERO, H. PETERSON, E. BALLESTA-ILLAN, A. PINEDA-LUCENA, M. DOMINGUEZ and J. MORANTE
Publicada:
12 oct 2021
Ahead of Print:
1 oct 2021
Resumen:
Fat stores are critical for reproductive success and may govern maturation initiation. Here, we report that signaling and sensing fat sufficiency for sexual maturation commitment requires the lipid carrier apolipophorin in fat cells and Sema1a in the neuroendocrine prothoracic gland (PG). Larvae lacking apolpp or Sema1a fail to initiate maturation despite accruing sufficient fat stores, and they continue gaining weight until death. Mechanistically, sensing peripheral body-fat levels via the apolipophorin/Sema1a axis regulates endocytosis, endoplasmic reticulum remodeling, and ribosomal maturation for the acquisition of the PG cells' high biosynthetic and secretory capacity. Downstream of apolipophorin/Sema1a, leptin-like upd2 triggers the cessation of feeding and initiates sexual maturation. Human Leptin in the insect PG substitutes for upd2, preventing obesity and triggering maturation downstream of Sema1a. These data show how peripheral fat levels regulate the control of the maturation decision-making process via remodeling of endomembranes and ribosomal biogenesis in gland cells.
Filiaciones:
S. JUAREZ-CARRENO:
Inst Neurociencias, Consejo Super Invest Cient CSIC, Campus St Joan,Apartado 18, Alicante 03550, Spain
Univ Miguel Hernandez, Campus St Joan,Apartado 18, Alicante 03550, Spain
D. VALLEJO:
Inst Neurociencias, Consejo Super Invest Cient CSIC, Campus St Joan,Apartado 18, Alicante 03550, Spain
Univ Miguel Hernandez, Campus St Joan,Apartado 18, Alicante 03550, Spain
J. CARRANZA-VALENCIA:
Inst Neurociencias, Consejo Super Invest Cient CSIC, Campus St Joan,Apartado 18, Alicante 03550, Spain
Univ Miguel Hernandez, Campus St Joan,Apartado 18, Alicante 03550, Spain
:
Ctr Invest Principe Felipe, Calle Eduardo Primo Yufera 3, Valencia 46012, Spain
P. RAMON-CANELLAS:
Inst Neurociencias, Consejo Super Invest Cient CSIC, Campus St Joan,Apartado 18, Alicante 03550, Spain
Univ Miguel Hernandez, Campus St Joan,Apartado 18, Alicante 03550, Spain
R. SANTORO:
Inst Neurociencias, Consejo Super Invest Cient CSIC, Campus St Joan,Apartado 18, Alicante 03550, Spain
Univ Miguel Hernandez, Campus St Joan,Apartado 18, Alicante 03550, Spain
E. DE HARTOG:
Inst Neurociencias, Consejo Super Invest Cient CSIC, Campus St Joan,Apartado 18, Alicante 03550, Spain
Univ Miguel Hernandez, Campus St Joan,Apartado 18, Alicante 03550, Spain
Univ Groningen, Groningen Inst Evolutionary Life Sci, Nijenborgh 7, NL-9747 AG Groningen, Netherlands
D. FERRES-MARCO:
Inst Neurociencias, Consejo Super Invest Cient CSIC, Campus St Joan,Apartado 18, Alicante 03550, Spain
Univ Miguel Hernandez, Campus St Joan,Apartado 18, Alicante 03550, Spain
A. ROMERO:
Inst Neurociencias, Consejo Super Invest Cient CSIC, Campus St Joan,Apartado 18, Alicante 03550, Spain
Univ Miguel Hernandez, Campus St Joan,Apartado 18, Alicante 03550, Spain
H. PETERSON:
Inst Neurociencias, Consejo Super Invest Cient CSIC, Campus St Joan,Apartado 18, Alicante 03550, Spain
Univ Miguel Hernandez, Campus St Joan,Apartado 18, Alicante 03550, Spain
E. BALLESTA-ILLAN:
Inst Neurociencias, Consejo Super Invest Cient CSIC, Campus St Joan,Apartado 18, Alicante 03550, Spain
Univ Miguel Hernandez, Campus St Joan,Apartado 18, Alicante 03550, Spain
:
Hosp Univ & Politecn La Fe, Inst Invest Sanitaria La Fe, Ave Fernando Abril Martorell 106, Valencia 46026, Spain
Univ Navarra, Ctr Invest Med Aplicada, Programa Terapias Mol, Ave Pio XII 55, Pamplona 31008, Spain
M. DOMINGUEZ:
Inst Neurociencias, Consejo Super Invest Cient CSIC, Campus St Joan,Apartado 18, Alicante 03550, Spain
Univ Miguel Hernandez, Campus St Joan,Apartado 18, Alicante 03550, Spain
J. MORANTE:
Inst Neurociencias, Consejo Super Invest Cient CSIC, Campus St Joan,Apartado 18, Alicante 03550, Spain
Univ Miguel Hernandez, Campus St Joan,Apartado 18, Alicante 03550, Spain
Green Published, Green Submitted, gold
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