Bacteroides uniformis CECT 7771 Modulates the Brain Reward Response to Reduce Binge Eating and Anxiety-Like Behavior in Rat
Por:
A. AGUSTI, I. CAMPILLO, T. BALZANO, A. BENITEZ-PAEZ, I. LOPEZ-ALMELA, M. ROMANI-PEREZ, J. FORTEZA, V. FELIPO, N. AVENA and Y. SANZ
Publicada:
1 oct 2021
Ahead of Print:
1 jul 2021
Resumen:
Food addiction (FA) is characterized by behavioral and neurochemical changes linked to loss of food intake control. Gut microbiota may influence appetite and food intake via endocrine and neural routes. The gut microbiota is known to impact homeostatic energy mechanisms, but its role in regulating the reward system is less certain. We show that the administration of Bacteroides uniformis CECT 7771 (B. uniformis) in a rat FA model impacts on the brain reward response, ameliorating binge eating and decreasing anxiety-like behavior. These effects are mediated, at least in part, by changes in the levels of dopamine, serotonin, and noradrenaline in the nucleus accumbens and in the expression of dopamine D1 and D2 receptors in the prefrontal cortex and intestine. B. uniformis reverses the fasting-induced microbiota changes and increases the abundance of species linked to healthy metabolotypes. Our data indicate that microbiota-based interventions might help to control compulsive overeating by modulating the reward response.
Filiaciones:
:
Spanish Council Sci Res IATA CSIC, Inst Agrochem & Food Technol, Microbial Ecol Nutr & Hlth Res Unit, Valencia, Spain
:
Spanish Council Sci Res IATA CSIC, Inst Agrochem & Food Technol, Microbial Ecol Nutr & Hlth Res Unit, Valencia, Spain
:
Ctr Invest Principe Felipe, Lab Neurobiol, Valencia, Spain
A. BENITEZ-PAEZ:
Spanish Council Sci Res IATA CSIC, Inst Agrochem & Food Technol, Microbial Ecol Nutr & Hlth Res Unit, Valencia, Spain
I. LOPEZ-ALMELA:
Spanish Council Sci Res IATA CSIC, Inst Agrochem & Food Technol, Microbial Ecol Nutr & Hlth Res Unit, Valencia, Spain
M. ROMANI-PEREZ:
Spanish Council Sci Res IATA CSIC, Inst Agrochem & Food Technol, Microbial Ecol Nutr & Hlth Res Unit, Valencia, Spain
:
Univ Catolica Valencia, Inst Valenciano Patol, Unidad Mixta Patol Mol, Ctr Invest Principe Felipe, Valencia, Spain
:
Ctr Invest Principe Felipe, Lab Neurobiol, Valencia, Spain
N. AVENA:
Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA
Y. SANZ:
Spanish Council Sci Res IATA CSIC, Inst Agrochem & Food Technol, Microbial Ecol Nutr & Hlth Res Unit, Valencia, Spain
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