The past, present, and future of breast cancer models for nanomedicine development
Por:
P. BOIX-MONTESINOS, P. SORIANO-TERUEL, A. ARMINAN, . MAR and M. VICENT
Publicada:
1 jun 2021
Ahead of Print:
1 abr 2021
Resumen:
Even given recent advances in nanomedicine development of breast cancer treatment in recent years and promising results in pre-clinical models, cancer nanomedicines often fail at the clinical trial stage. Limitations of conventional in vitro models include the lack of representation of the stromal population, the absence of a three-dimensional (3D) structure, and a poor representation of inter-tumor and intratumor heterogeneity. Herein, we review those cell culture strategies that aim to overcome these limitations, including cell co-cultures, advanced 3D cell cultures, patient-derived cells, bioprinting, and microfluidics systems. The in vivo evaluation of nanomedicines must consider critical parameters that include the enhanced permeability and retention effect, the host's immune status, and the site of tumor implantation. Here, we critically discuss the advantages and limitations of current in vivo models and report how the improved selection and application of breast cancer models can improve the clinical translation of nanomedicines. (c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Filiaciones:
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Ctr Invest Principe Felipe, Polymer Therapeut Lab, Av Eduardo Primo Yufera 3, E-46012 Valencia, Spain
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Ctr Invest Principe Felipe, Polymer Therapeut Lab, Av Eduardo Primo Yufera 3, E-46012 Valencia, Spain
Ctr Invest Principe Felipe, Targeted Therapies Canc & Inflammat Lab, Av Eduardo Primo Yufera 3, E-46012 Valencia, Spain
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Ctr Invest Principe Felipe, Polymer Therapeut Lab, Av Eduardo Primo Yufera 3, E-46012 Valencia, Spain
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Ctr Invest Principe Felipe, Targeted Therapies Canc & Inflammat Lab, Av Eduardo Primo Yufera 3, E-46012 Valencia, Spain
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Ctr Invest Principe Felipe, Polymer Therapeut Lab, Av Eduardo Primo Yufera 3, E-46012 Valencia, Spain
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