Hepatic steatosis and steatohepatitis: a functional meta-analysis of sex-based differences in transcriptomic studies.
Por:
Català-Senent JF, Hidalgo MR, Berenguer M, Parthasarathy G, Malhi H, Malmierca-Merlo P, de la Iglesia-Vayá M and García-García F
Publicada:
25 mar 2021
Resumen:
Previous studies have described sex-based differences in the epidemiological and clinical patterns of non-alcoholic fatty liver disease (NAFLD); however, we understand relatively little regarding the underlying molecular mechanisms. Herein, we present the first systematic review and meta-analysis of NAFLD transcriptomic studies to identify sex-based differences in the molecular mechanisms involved during the steatosis (NAFL) and steatohepatitis (NASH) stages of the disease.
Filiaciones:
:
Bioinformatics and Biostatistics Unit, Principe Felipe Research Center, Valencia, Spain
Spanish National Bioinformatics Institute, ELIXIR-Spain (INB, ELIXIR-ES), Madrid, Spain
:
Bioinformatics and Biostatistics Unit, Principe Felipe Research Center, Valencia, Spain.
Berenguer M:
Liver Transplantation and Hepatology Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain
Grupo de Hepatología, Cirugía HBP y Trasplantes, Instituto de Investigación Sanitaria La Fe, Valencia, Spain
CIBERehd, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain
Department of Medicine, Universitat de València, Valencia, Spain
Parthasarathy G:
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA
Malhi H:
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA
:
Bioinformatics and Biostatistics Unit, Principe Felipe Research Center, Valencia, Spain
Atos Research & Innovation (ARI), Madrid, Spain
:
Biomedical Imaging Unit FISABIO-CIPF, Fundación para el Fomento de la Investigación Sanitario y Biomédica de la Comunidad Valenciana, Valencia, Spain
:
Spanish National Bioinformatics Institute, ELIXIR-Spain (INB, ELIXIR-ES), Madrid, Spain.
Gold, Green Published
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