Surfactant-Triggered Molecular Gate Tested on Different Mesoporous Silica Supports for Gastrointestinal Controlled Delivery
Por:
E. POYATOS-RACIONERO, I. GONZALEZ-ALVAREZ, M. GONZALEZ-ALVAREZ, R. MARTINEZ-MANEZ, M. MARCOS, A. BERNARDOS and E. AZNAR
Publicada:
1 jul 2020
Resumen:
In recent decades, the versatility of mesoporous silica particles and their relevance to develop controlled release systems have been demonstrated. Within them, gated materials able to modulate payload delivery represent great advantages. However, the role played by the porous matrix in this kind of systems is scarce. In this work, different mesoporous silica materials (MCM-41, MCM-48, SBA-15 and UVM-7) are functionalized with oleic acid as a molecular gate. All systems are fully characterized and their ability to confine the entrapped cargo and release it in the presence of bile salts is validated with release assays and in vitro digestion experiments. The cargo release profile of each synthesized support is studied, paying attention to the inorganic scaffold. Obtained release profiles fit to Korsmeyer-Peppas model, which explains the differences among the studied supports. Based on the results, UVM-7 material was the most appropriate system for duodenal delivery and was tested in an in vivo model of the Wistar rat. Payload confinement and its complete release after gastric emptying is achieved, establishing the possible use of mesoporous silica particles as protection and direct release agents into the duodenum and, hence, demonstrating that these systems could serve as an alternative to the administration methods employed until now.
Filiaciones:
E. POYATOS-RACIONERO:
CIBER Bioingn Biomat & Nanomed CIBER BBN, Valencia 46022, Spain
Univ Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Univ Politecn Valencia, Camino Vera S-N, Valencia 46022, Spain
I. GONZALEZ-ALVAREZ:
Univ Miguel Hernandez, Dept Ingn, Secc Farm & Tecnol Farmaceut, Alicante 03550, Spain
M. GONZALEZ-ALVAREZ:
Univ Miguel Hernandez, Dept Ingn, Secc Farm & Tecnol Farmaceut, Alicante 03550, Spain
:
CIBER Bioingn Biomat & Nanomed CIBER BBN, Valencia 46022, Spain
Univ Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Univ Politecn Valencia, Camino Vera S-N, Valencia 46022, Spain
Univ Politecn Valencia, Inst Invest Sanitaria La Fe, Unidad Mixta Invest Nanomed & Sensores, Av Fernando Abril Martorell 106, Valencia 46026, Spain
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermeda, C Eduardo Primo Yufera 3, Valencia 46100, Spain
Univ Politecn Valencia, Dept Quim, Camino Vera S-N, Valencia 46022, Spain
:
CIBER Bioingn Biomat & Nanomed CIBER BBN, Valencia 46022, Spain
Univ Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Univ Politecn Valencia, Camino Vera S-N, Valencia 46022, Spain
Univ Politecn Valencia, Inst Invest Sanitaria La Fe, Unidad Mixta Invest Nanomed & Sensores, Av Fernando Abril Martorell 106, Valencia 46026, Spain
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermeda, C Eduardo Primo Yufera 3, Valencia 46100, Spain
Univ Politecn Valencia, Dept Quim, Camino Vera S-N, Valencia 46022, Spain
:
CIBER Bioingn Biomat & Nanomed CIBER BBN, Valencia 46022, Spain
Univ Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Univ Politecn Valencia, Camino Vera S-N, Valencia 46022, Spain
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermeda, C Eduardo Primo Yufera 3, Valencia 46100, Spain
:
CIBER Bioingn Biomat & Nanomed CIBER BBN, Valencia 46022, Spain
Univ Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Univ Politecn Valencia, Camino Vera S-N, Valencia 46022, Spain
Univ Politecn Valencia, Inst Invest Sanitaria La Fe, Unidad Mixta Invest Nanomed & Sensores, Av Fernando Abril Martorell 106, Valencia 46026, Spain
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermeda, C Eduardo Primo Yufera 3, Valencia 46100, Spain
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