Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy
Por:
C. SAN MARTIN-VALENZUELA, A. BORRAS-BARRACHINA, J. GALLEGO, A. URIOS, V. MESTRE-SALVADOR, P. CORREA-GHISAYS, M. BALLESTER, D. ESCUDERO-GARCIA, J. TOSCA, C. MONTON, M. RIOS, E. KOSENKO, V. FELIPO, R. TABARES-SEISDEDOS, G. SELVA-VERA and C. MONTOLIU
Publicada:
1 jul 2020
Resumen:
Minimal hepatic encephalopathy (MHE) is associated with mild cognitive impairment and frailty. This study aims to identify cognitive and motor differences in cirrhotic patients with and without MHE, and the correlations between motor signs and cognitive performance. Gait, balance, hand strength and motor speed performance were evaluated in 66 cirrhotic patients (38 without and 28 with MHE, according to the Psychometric Hepatic Encephalopathy Score (PHES). Cognitive performance was measured with the Mini-Mental State Examination, Verbal Fluency Test, Aprendizaje Verbal Espana-Complutense Test (TAVEC), Wechsler Adult Intelligence Scale III, Hamilton Depression and Anxiety Rating Scale and Functioning Assessment Short Test (FAST). MHE patients performed worse than patients without MHE in cognitive and autonomous functioning, learning and long-term memory, and verbal fluency. The same pattern was found in gait, center of pressure movement, variability of hand strength performance and hand motor speed. In MHE patients, high correlations were found between balance and FAST test, gait velocity and verbal skills, hand strength variability and anxiety and depression, and motor speed and FAST and TAVEC. MHE patients showed worse motor and cognitive performance than patients without MHE. MHE patients could have impaired movement control expressed as bradykinesia, and this reduced motor performance could correlate with cognitive performance.
Filiaciones:
C. SAN MARTIN-VALENZUELA:
Univ Valencia, Fac Med, Unit Personal Auton Dependency & Mental Disorder, Valencia 46010, Spain
Univ Valencia, Fac Physiotherapy, Dept Physiotherapy, Valencia 46010, Spain
CIBERSAM, Ctr Invest Biomed Red Salud Mental, Madrid 28029, Spain
A. BORRAS-BARRACHINA:
Univ Valencia, Fac Med, Unit Personal Auton Dependency & Mental Disorder, Valencia 46010, Spain
J. GALLEGO:
INCLIVA, Hlth Res Inst, Valencia 46010, Spain
:
INCLIVA, Hlth Res Inst, Valencia 46010, Spain
V. MESTRE-SALVADOR:
Univ Valencia, Fac Med, Unit Personal Auton Dependency & Mental Disorder, Valencia 46010, Spain
P. CORREA-GHISAYS:
CIBERSAM, Ctr Invest Biomed Red Salud Mental, Madrid 28029, Spain
Univ Valencia, Fac Psychol, Valencia 46010, Spain
M. BALLESTER:
INCLIVA, Hlth Res Inst, Valencia 46010, Spain
Hosp Clin Univ Valencia, Digest Med Unit, Valencia 46010, Spain
D. ESCUDERO-GARCIA:
Hosp Clin Univ Valencia, Digest Med Unit, Valencia 46010, Spain
Univ Valencia, Fac Med, Dept Med, Valencia 46010, Spain
J. TOSCA:
Hosp Clin Univ Valencia, Digest Med Unit, Valencia 46010, Spain
C. MONTON:
Hosp Clin Univ Valencia, Digest Med Unit, Valencia 46010, Spain
M. RIOS:
Arnau de Vilanova Hosp, Digest Serv, Valencia 46015, Spain
E. KOSENKO:
Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142290, Russia
:
Principe Felipe Res Ctr, Lab Neurobiol, Valencia 46012, Spain
R. TABARES-SEISDEDOS:
Univ Valencia, Fac Med, Unit Personal Auton Dependency & Mental Disorder, Valencia 46010, Spain
CIBERSAM, Ctr Invest Biomed Red Salud Mental, Madrid 28029, Spain
Univ Valencia, Fac Med, Dept Med, Valencia 46010, Spain
G. SELVA-VERA:
Univ Valencia, Fac Med, Unit Personal Auton Dependency & Mental Disorder, Valencia 46010, Spain
CIBERSAM, Ctr Invest Biomed Red Salud Mental, Madrid 28029, Spain
Hosp Clin Univ Valencia, Unit Psychiat & Psychol Med, Valencia 46010, Spain
:
INCLIVA, Hlth Res Inst, Valencia 46010, Spain
Univ Valencia, Fac Med, Dept Pathol, Valencia 46010, Spain
Gold, Green Published
|