Enteric neurons show a primary cilium
Por:
M. LUESMA, I. CANTARERO, T. CASTIELLA, M. SORIANO, J. GARCIA-VERDUGO and C. JUNQUERA
Publicada:
1 ene 2013
Resumen:
The primary cilium is a non-motile cilium whose structure is 9+0. It is involved in co-ordinating cellular signal transduction pathways, developmental processes and tissue homeostasis. Defects in the structure or function of the primary cilium underlie numerous human diseases, collectively termed ciliopathies. The presence of single cilia in the central nervous system (CNS) is well documented, including some choroid plexus cells, neural stem cells, neurons and astrocytes, but the presence of primary cilia in differentiated neurons of the enteric nervous system (ENS) has not yet been described in mammals to the best of our knowledge. The enteric nervous system closely resembles the central nervous system. In fact, the ultrastructure of the ENS is more similar to the CNS ultrastructure than to the rest of the peripheral nervous system. This research work describes for the first time the ultrastructural characteristics of the single cilium in neurons of rat duodenum myenteric plexus, and reviews the cilium function in the CNS to propose the possible role of cilia in the ENS cells.
Filiaciones:
M. LUESMA:
Univ Zaragoza, Fac Med, Dept Human Anat & Histol, E-50009 Zaragoza, Spain
Sci Res Ctr Aragon, Aragon Hlth Res Inst IIS Aragon, Zaragoza, Spain
I. CANTARERO:
Univ Zaragoza, Fac Med, Dept Human Anat & Histol, E-50009 Zaragoza, Spain
Sci Res Ctr Aragon, Aragon Hlth Res Inst IIS Aragon, Zaragoza, Spain
T. CASTIELLA:
Sci Res Ctr Aragon, Aragon Hlth Res Inst IIS Aragon, Zaragoza, Spain
:
Principe Felipe Res Ctr, Cell Biol Lab, Valencia, Spain
:
Principe Felipe Res Ctr, Cell Biol Lab, Valencia, Spain
C. JUNQUERA:
Univ Zaragoza, Fac Med, Dept Human Anat & Histol, E-50009 Zaragoza, Spain
Sci Res Ctr Aragon, Aragon Hlth Res Inst IIS Aragon, Zaragoza, Spain
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