Relevant Physicochemical Descriptors of "Soft Nanomedicines" to Bypass Biological Barriers
Por:
A. NINO-PARIENTE, V. NEBOT and M. VICENT
Publicada:
1 ene 2016
Resumen:
Herein, we present an overview on the current status of the characterization techniques and methodologies used to study the physicochemical descriptors that influence the final clinical performance of a given nanomedicine. The described techniques were selected based on their suitability to operate under relevant "native" conditions that mimic the physiological environment. Special emphasis is placed on those techniques that hold a greater potential to unravel dynamic, structural, and compositional features of soft organic nanomedicines relevant to the ability to bypass biological barriers, and hence allow for the rational design of drug delivery platforms with improved biological output.
Filiaciones:
A. NINO-PARIENTE:
Ctr Invest Principe Felipe, Polymer Therapeut Lab, C Eduardo Primo Yufera 3, Valencia 46012, Spain
:
Ctr Invest Principe Felipe, Polymer Therapeut Lab, C Eduardo Primo Yufera 3, Valencia 46012, Spain
Polypeptide Therapeut Solut SL Valencia, Valencia, Spain
:
Ctr Invest Principe Felipe, Polymer Therapeut Lab, C Eduardo Primo Yufera 3, Valencia 46012, Spain
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