Capturing "Extraordinary" Soft-Assembled Charge-Like Polypeptides as a Strategy for Nanocarrier Design
Por:
A. DURO-CASTANO, V. NEBOT, A. NINO-PARIENTE, A. ARMINAN, J. ARROYO-CRESPO, A. PAUL, N. FEINER-GRACIA, L. ALBERTAZZI and M. VICENT
Publicada:
18 oct 2017
Resumen:
The rational design of nanomedicines is a challenging task given the complex architectures required for the construction of nanosized carriers with embedded therapeutic properties and the complex interface of these materials with the biological environment. Herein, an unexpected charge-like attraction mechanism of self-assembly for star-shaped polyglutamates in nonsalty aqueous solutions is identified, which matches the ubiquitous "ordinary-extraordinary" phenomenon previously described by physicists. For the first time, a bottom-up methodology for the stabilization of these nanosized soft-assembled star-shaped polyglutamates is also described, enabling the translation of theoretical research into nanomaterials with applicability within the drug-delivery field. Covalent capture of these labile assemblies provides access to unprecedented architectures to be used as nanocarriers. The enhanced in vitro and in vivo properties of these novel nanoconstructs as drug-delivery systems highlight the potential of this approach for tumor-localized as well as lymphotropic delivery.
Filiaciones:
:
Ctr Invest Principe Felipe, Polymer Therapeut Lab, Av Eduardo Primo Yufera 3, Valencia 46012, Spain
:
Ctr Invest Principe Felipe, Polymer Therapeut Lab, Av Eduardo Primo Yufera 3, Valencia 46012, Spain
A. NINO-PARIENTE:
Ctr Invest Principe Felipe, Polymer Therapeut Lab, Av Eduardo Primo Yufera 3, Valencia 46012, Spain
:
Ctr Invest Principe Felipe, Polymer Therapeut Lab, Av Eduardo Primo Yufera 3, Valencia 46012, Spain
:
Ctr Invest Principe Felipe, Polymer Therapeut Lab, Av Eduardo Primo Yufera 3, Valencia 46012, Spain
A. PAUL:
Cardiff Univ, Sch Chem, Main Bldg,Pk Pl, Cardiff CF10 3AT, S Glam, Wales
N. FEINER-GRACIA:
Barcelona Inst Sci & Technol, Inst Bioengn Catalonia IBEC, Carrer Baldiri Reixac 15-21, Barcelona 08028, Spain
L. ALBERTAZZI:
Barcelona Inst Sci & Technol, Inst Bioengn Catalonia IBEC, Carrer Baldiri Reixac 15-21, Barcelona 08028, Spain
:
Ctr Invest Principe Felipe, Polymer Therapeut Lab, Av Eduardo Primo Yufera 3, Valencia 46012, Spain
Green Published, Green Accepted, Hybrid Gold
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