Organocatalytic anti-Selective Mannich Reactions with Fluorinated Aldimines: Synthesis of anti-gamma-Fluoroalkyl-gamma-amino Alcohols
Por:
S. FUSTERO, F. MOJARRAD, M. CARRION, J. SANZ-CERVERA and J. ACENA
Publicada:
1 oct 2009
Resumen:
The asymmetric Mannich reaction between fluoroalkyl aldimines and aldehydes catalyzed by alpha,alpha-diphenylprolinol trimethylsilyl ether is reported. The corresponding Mannich adducts were reduced in situ to afford anti-beta-alkyl-gamma-fluoroalkyl-gamma-amino alcohols in moderate yields and with very high diastereo- and enantioselectivities. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Filiaciones:
:
Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Spain
Ctr Invest Principe Felipe, Lab Mol Organ, Valencia 46012, Spain
F. MOJARRAD:
Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Spain
M. CARRION:
Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Spain
J. SANZ-CERVERA:
Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Spain
Ctr Invest Principe Felipe, Lab Mol Organ, Valencia 46012, Spain
J. ACENA:
Ctr Invest Principe Felipe, Lab Mol Organ, Valencia 46012, Spain
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